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The Hostynek and Maibach group at UCSF measured exactly this in 2011: human skin permeation of GHK-Cu as a function of skin layer, with the result that the peptide accumulates in the upper stratum corneum but does not pass through to viable epidermis or dermis in any meaningful quantity 4

10.1038/ajg.2013.451 [DOI] [PubMed] [Google Scholar] Atreya R., Mudter J., Finotto S., Mllberg J., Jostock T., Wirtz S., et al

Animal studies show BPC-157 accelerates tendon-to-bone healing, improves collagen organization, and reduces inflammatory markers in tendon tissue

Levels naturally decline with age, which may contribute to fatigue, slower recovery, and decreased metabolic resilience