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The decline in NO synthesis can lead to endothelial activation by upregulating adhesion molecules, including intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), E-selectin, and macrophage chemoattractant peptide-1 (MCP-1) [55]
Enjalbert B, Smith DA, Cornell MJ, Alam I, Nicholls S, et al
The olfactory pathway is typically associated with delivery to the olfactory bulb and forebrain regions, whereas the trigeminal route is commonly linked to distribution patterns involving brainstem-associated structures ( e.g
10.1016/j.freeradbiomed.2009.07.028 Free Radic Biol
