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In the most recent series only one fatal melanoma occurred in 224 patients studied with a mean follow-up of 8 years [36], although 5/349 patients reported in a second paper from the same institution with overlapping cases (mean prospective follow-up of 9.2 years) developed melanoma (1.4%) [43]

Moreover, studies have shown that atherosclerosis usually precedes ischemic heart disease (Panizzi et al., 2010), and that atherosclerosis induces myocardial infarction, which leads to a drastic reduction in myocardial contractility, dilation of the left ventricle, and a significant reduction in the hearts pumping capacity, which can easily lead to heart failure (Swirski and Nahrendorf, 2013)

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