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Description
39 These proteases, including elastase and matrix metalloproteinases (MMPs) released from activated macrophages, neutrophils and epithelial cells, degrade components of the extracellular matrix (ECM), elastin fibers and collagen, generating elastin fragments or collagen-derived peptides, which contributes to the development of emphysema
Neuroinflammation is initiated primarily by the activation of microglia, the resident immune cells of the central nervous system (Fornari Laurindo et al
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