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2.1.2 Dysregulation of key iron-regulating proteins In ferroptosis, intracellular iron homeostasis is maintained by a network of regulatory mechanisms, including iron acquisition via the transferrin (Tf)/transferrin receptor 1 (TfR1) pathway, intracellular transport by divalent metal transporter 1 (DMT1), export by ferroportin (FPN1), storage in ferritin, and iron release through ferritinophagy mediated by nuclear receptor coactivator 4 (NCOA4) (39, 40)

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In nrf2a5 homozygous mutants, the expression of tsh- was greatly increased compared with their WT siblings (Fig 2S, second from the left), consistent with the known effects of a lack of T.H

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It attracts moisture from the air to stay active longer

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doi: 10.1016/j.cmet.2005.02.005 52 MaSHensonESChenYGibsonSB

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