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Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited therapeutic options and a profoundly immunosuppressive tumor microenvironment (TME)
Schaeffer, J., Gallay, O
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
In the liver, a portion of the drug gets metabolized and significantly excreted, decreasing the bioactive drug concentration before it reaches systemic circulation [28]
