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The estimated treatment ratios of the mean AUC 0 of cagrilintide in each of the renal impairment groups to the normal renal function group were 1.23 (90% CI, 0.911.66) for the mild renal impairment group, 1.18 (90% CI, 0.871.59) for the moderate renal impairment group and 1.21 (90% CI, 0.871.68) for the severe renal impairment group

[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy

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