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Deficiency of GPx1 also promotes pro-inflammatory activation of endothelial and other cell types, and accelerates atherogenesis in susceptible animal models [6, 78, 79, 84, 85]

An imbalance in favor of antioxidants can lead to so-called antioxidative stress, which may also have harmful effects, particularly when synthetic antioxidants are consumed in excessive amounts [165]

Summary: No glutathione supplement is currently recommended by NICE or the NHS for treating fatty liver disease, though N-acetylcysteine (NAC) has the strongest evidence base among glutathione precursors

Typical oral doses range from 100500 mg daily in divided doses, though tolerance and liver safety must be monitored closely, especially in patients with compromised hepatic function