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Specifically, one double-blind trial in 140 patients with chronic schizophrenia, described by the Cochrane Collaboration as a high quality trial that measured clinically-useful outcomes (Positive and Negative Syndrome Scale [PANSS] and Clinical Global Impression [CGI]) over a longer period of time [145], compared adjunctive NAC versus placebo [146]

These include antidepressants such as duloxetine and milnacipran (serotoninnorepinephrine reuptake inhibitors), tricyclic antidepressants such as amitriptyline, central nervous system depressants such as zolpidem, voltage-gated Ca + channel inhibitors including pregabalin and gabapentin, muscle relaxants such as cyclobenzaprine orally disintegrating tablets, and opioid analgesics such as tramadol and oxycodone

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