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doi: 10.1021/bi901180v
At the same time, OS can promote the proliferation of theca-interstitial cells, upregulate CYP17, reduce serum SHBG levels, increase androgen secretion, improve the biological activity of serum free testosterone, and cause HA
Considering the clinical values of tamoxifen in treatment of breast cancer, it is clear that preventing and overcoming tamoxifen resistance remains important clinical goals
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