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So what explains the difference

The localized heat generated by RF can also temporarily increase lipid fluidity in the stratum corneum, promoting fusion of liposomal bilayers with disrupted skin lipids and enhancing the release of encapsulated drugs [261]

GPX4 released from ferroptotic cancer cells functions as a DAMP that suppresses antitumor immunity by engaging the zona pellucida glycoprotein 3 (ZP3) receptor on dendritic cells 101

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