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Mentz RJ, Anker SD, Pitt B, et al

When it comes to supplements, taking high doses of vitamin C at the same time as your B12 shot might slightly lower the amount of B12 your body can use, but this is more relevant for oral B12 supplements than injections

About 1020% of patients are non-responders or modest responders

Chronic kidney disease patients often demonstrate elevated B12 levels, particularly those on dialysis