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Step 1: Kisspeptin-10 activates KISS1R receptors in the hypothalamus Step 2: GnRH neurons release gonadotropin-releasing hormone in pulses Step 3: The pituitary gland responds by secreting LH and FSH Step 4: LH stimulates Leydig cells to produce testosterone Step 5: FSH supports spermatogenesis through Sertoli cells Natural kisspeptin levels in blood plasma decline significantly with age

Secondly, metabolites also activate a large number of immune factors to defend against pathogens

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The key mediator is hepcidin, which traps iron within macrophages and enterocytes, reducing its availability for red blood cell production