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The peak paralysis is usually reached within 4 to 6 weeks.[ref] Many GBS patients require extended hospitalization
Tests in bacteria, cells, and mice all came back negative, suggesting the compound does not pose carcinogenic risk through DNA damage mechanisms
The presence of the D1236 (from MRP2 substitution) instead of G1228 (wild-type MRP1) in the chimera M8 could create a steric hindrance, as shown by the Cryo-EM apo and LTC 4 bound (inward-facing) structures of bovine MRP1 40,44 (Fig
doi: 10.1038/sj.cdd.4401150
