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Schwingel et al (11) treated BALB/c mice with OXA (10 mg/kg/week, i.p.), and reported the appearance of steatohepatitis after 6 weeks of OXA treatment

Ann Rev Nutr 1:401425 Hirschberger LL, De La Rosa J, Stipanuk MH (1985) Determination of cysteinesulfinate, hypotaurine and taurine in physiological samples by reversed-phase high-performance liquid chromatography

10.1001/archotol.1988.01860130049013 Arch

Peripherally restricted analgesics that target only peripheral opioid receptors, but not those in the central nervous system, could provide sufficient analgesia ( Sleep loss/deprivation as a modulator of the opioid mediated analgesia Numerous studies have investigated the impact of experimental sleep disturbances on pain perception (Moldofsky, 1995