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Description
Thus, histamine intolerance is the clinical condition that describes the inability of certain individuals to degrade histamine and results in the onset of symptoms caused by its accumulation in the blood (Figure 3)
GABAergic signaling plays a central role in reducing cortical excitability and promoting slow-wave synchronization

In summary, our study supports that MeCbl, a widely prescribed drug, is promisingly repurposed to be an effective therapeutic option to GSDME dependent liver failure, which is characterized with high morbidity and high mortality without efficient clinical therapies

DON (6-Diazo-5-oxo-L-norleucine), as the first-generation glutamine antimetabolite, irreversibly inhibits the active site of glutaminease
