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A reduction in antioxidant enzymatic activity in patients with hypertension has been reported

Overall, the 24-week supplementation with anti-atherosclerotic liquid (AAL), anti-inflammatory capsules (AIC) and antioxidant liquid (AOL) was associated with broad improvements in metabolic, vascular, oxidative, and inflammatory parameters, without negatively impacting renal or hematological markers, highlighting the potential health-supporting benefits of these natural compounds in healthy individuals

Under oxidative stress, Trx separates from ASK1, activating ASK1

Dubland JA, Francis GA (2015) Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism