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These proteins have a wide range of functions, including signal transduction, cell proliferation, transcription, apoptosis, neuronal differentiation, cell migration, regulation of ion channels and cell survival ( Alpha-internexin (INA) is a critical component of the cytoskeletal protein network and an essential component of neurofilaments, which are the most abundant protein in the human brain

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Eur J Pharmacol 437(3):139145 Van Hemelrijck A, Hachimi-Idrissi S, Sarre S, Ebinger G, Michotte Y (2005) Neuroprotective effect of N-acetyl-aspartyl-glutamate in combination with mild hypothermia in the endothelin-1 rat model of focal cerebral ischaemia