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Zonula Occludens The ZO proteins were the first TJ-specific proteins identified and three ZO proteins, ZO-1, -2, and -3, have been identified to date.35 According to sequence analysis, these ZO proteins are categorized as members of the membrane-associated guanylate kinase homolog family.17 They are multi-domain proteins carrying three post-synaptic density 95/Drosophila disc large/zona-occludens (PDZ) domains, a Src homology-3 domain and a region of homology to guanylate kinase homolog from the side of the N-terminus (Fig

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Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy