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A: 30 minutes before beginning testing rats were given scopolamine directly into the brain intracerebroventricularly (ICV) and 10 minutes later Dihexa was given ICV at 10 pmoles (low dose) or 100 pmoles (high dose)

The supply pathway involves the export of GSH from astrocytes via the multidrugresistance protein 1 (Mrp1), extracellular processing of GSH by astrocytic glutamyl transpeptidase (GT) to the dipeptide cysteinylglycine (CysGly) and hydrolysis of this dipeptide by neuronal aminopeptidase N (ApN) to cysteine (Cys) and glycine (Gly)

Molecular mechanisms of inflammasome activation during microbial infections

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