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Beta-blockers (e.g., bisoprolol) reduce SNS overdrive, lowering heart rate and RV strain in HF patients and easing pulmonary workload in COPD patients, with clinical trials showing improved ejection fraction

Fatigue in multiple sclerosis is associated with reduced expression of interleukin-10 and worse prospective disease activity

The half-life of the macrophage precursor, the blood monocytes, is about 1 day, whereas the life span of tissue macrophages is several months or years
