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APPROACH, A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Patients With Familial Chylomicronemia Syndrome

The restoration of adipose function not only enhances lipid clearance but also reduces hepatic steatosis and pancreatic stress, potentially explaining the improvements in liver enzymes (ALT, AST) and glucose tolerance observed in our study

Neurosci Biobehav Rev 98: 234255, 2019

In a different trial, Wachter et al., reported that supplementation with 2 g of l-carnitine given twice daily for a period of 3 months did not alter l-carnitine muscle levels [30]
