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Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

Oxidative stress can also impact signaling pathways such as adenosine monophosphate kinase (AMPK) and the peroxiredoxin (Prdx) system, potentially compromising cellular antioxidant defenses controlled by NRF2 (Lee and Kim 2013

Indeed, we observed that SGAs possess DAO-inhibitory activity in vitro (data not shown)
