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Description
The EPR effect is a consequence of the development of abnormal vasculature within the growing tumor with functional and anatomical abnormalities

As a result, pain is also highly associated with psychiatric comorbidities resulting in more severe pain, worse functioning and disability, lower quality-of-life, and higher incidences of opioid-use disorder [21]

Voutilainen S, Morrow JD, Roberts LJ II, Alfthan G, Alho H, Nyyssnen K, and Salonen JT (1999)

[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Laakso M., Fernandes Silva L
