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Muscle loss is a significant practical concern, with studies showing that 30-40% of weight lost on GLP-1 agonists can be lean mass if protein intake and resistance training are neglected

High levels of sugar in the blood (hyperglycemia) and insulin deficiency or resistance can lead to increased oxidative stress

Chronic vitamin D toxicity can lead calcification of numerous soft tissues and may ultimately result in permanent renal failure

Genes Dis (2014) 1(1):87105
