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Function of BA in treatment of neurological diseases: the neuroprotective roles UDCA and its taurine-conjugated derivative TUDCA are regarded as the most hydrophilic BA [124]

In addition to their anti-inflammatory effects, these compounds have inhibitory effects on the following pathways: inflammasome (NLRP3), Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, endothelial cell vascular cell adhesion molecule-1 (VCAM-1) or intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinases involved in remodelling and metastasis (MMP 2, MMP 9), and chronic cycloxogenase derived prostaglandins that promote angiogenesis and immunosuppression (182)

Reported reactions include injection-site redness/itch, transient flushing and histamine-type reactions

Chromatin was fragmented via sonication (20 cycles of 30 s on/off) using a Bioruptor