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It is also important to consider that the identification of cell types responsible for Fc-dependent antibody-mediated protection in mice (and other animal models) does not necessarily translate directly to humans owing to factors including differences in the FcR expression profile of these cells (Table 1) and differences in the relative abundance of these cell types in tissues and in circulation

He also hypothesized that senolytic drugs can selectively eliminate senescent cells from patients with SLE and rejuvenate these tissues, improve organ function, and promote disease dormancy

10.1210/jc.86.8.3574
