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The evolution of melatonin presumably occurred concurrently in both photosynthesizing cyanobacteria and in non-photosynthesizing bacteria, e.g., -proteobacteria, of which multiple types share a common ancestor (65)

Conversely, elevated IL-22 expression promotes the aggregation of B cells and the formation of lymphoid aggregates, resulting in the upregulation of multiple cytokines including CXCL12 and CXCL13, ultimately leading to the production of autoantibodies (52)

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Aquaporin-9 immunohistochemistry in varicocele testes as a consequence of hypoxia in the sperm production site