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Additionally, consuming a plant-based diet containing soy, legumes, and quinoa, dietary supplements rich in omega-3 and fermented foods significantly decreases TMAO levels, according to other studies [77, 82]

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Second, we integrate recent molecular evidence spanning both classical and emerging pathways in lipid metabolism (including AMPK, SIRT1, PPAR, and PGC1) as well as metabolicinflammatory signaling related to insulin resistance (e.g., activation of IGF-1/AKT and inhibition of NF-B)

Pain 159 , 469480 (2018)