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Studies highlight that vitamin B12, along with folate, is needed as a major determinant of one-carbon metabolism, which produces the compound called SAM-e ( S-adenosyl methionine)

It is speculated that SARS-CoV-2 infection could exacerbate this mechanism by depleting Treg cells or diminishing their function due to suppression of FoxP3 ( 2.2 Autoreactive T cell activation and infiltration in the pancreas Beyond the failures of central and peripheral tolerance, the progression of T1D relies on the precise mechanisms by which autoreactive T cells are presented with self-antigens in the periphery

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