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Patients with genetic defects in four of the six γ-glutamyl cycle enzymes...

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While oral supplements exist, intravenous (IV) or intramuscular (IM) administration provides higher bioavailability, ensuring the body absorbs and utilizes the full dose efficiently.

Treatment with intranasal cyanocobalamin should be delayed until symptoms resolve in patients with nasal congestion, allergic rhinitis, and upper respiratory infection
