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Intervention Strategies: Anti-VEGF neutralizing antibodies (e.g., bevacizumab/B20) or anti-angiogenic tyrosine kinase inhibitors (e.g., axitinib), by blocking VEGF signaling, not only reduce pathological angiogenesis, edema, and hemorrhage but also decrease peripheral nerve density mediated by the interaction of VEGF with neuropilin (NRP), thereby alleviating pain

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