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Growing evidence indicates that metabolic disturbances (particularly mitochondrial dysfunction) are central drivers of maladaptive microglial behavior in AD (Yang et al., 2025)
This is referred to as de novo synthesis of choline
Sirt1 protects against high-fat diet-induced metabolic damage
Huang et al., 2015) indicates its essential application in the other tissues healing, particularly, the muscle (Figures 912), tendon (Figure 12), ligament, and bone (Figure 13) (Sikiric et al., 1993
