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The problem with carnitine Muscle takes up carnitine against a very large (about 1,000-fold) concentration gradient (plasma carnitine is 40-60 mol/L and muscle carnitine is 4-5 mmol/L)

Yet, de novo choline synthesis in humans is not sufficient to meet their metabolic needs such that healthy humans fed choline-deficient diets develop fatty liver, liver damage, and/or muscle damage (see Deficiency)

Crystal lattice reflects in situ S-layer assembly Due to the propensity of S-layer proteins to spontaneously self-assemble into 2D arrays 20 , we hypothesised that the packing of our crystal structures might be reflective of native S-layer assembly

Early life [edit] Howell was born in the Van Nuys neighborhood of Los Angeles to Christopher N