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[58] Another study using intravenous infusion of n-acetylcysteine (2 hour infusion of 150 mg/kg, followed by 15 mg/kg/hour for 5 days) resulted in significantly reduced digital ulcers and lower mean recovery time on cold challenge test in 22 patients of systemic sclerosis

Ideally, one would use a lower or mid dose cream and apply twice per day until stable levels are met
PMID: 20406950

For instance, Behnammanesh et al., proved that canagliflozin, but not empagliflozin or dapagliflozin, inhibits VSMCs proliferation and migration in pharmacologically relevant concentrations (Behnammanesh et al
