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Conclusions Artemisinin and its derivatives exhibit more potent antimalarial activity than iron chelators, likely stemming from their ability to accumulate in the parasites digestive vacuoles, interact more effectively with heme and iron, and thereby disrupt heme/iron homeostasis and utilization

10.1093/hmg/ddv007 80 PrudovaA.BaumanZ.BraunA.VitvitskyV.LuS

In vitro, apigenin treatment (10, 20 M) improved cell viability, inhibited ROS production, and reversed stimulation-induced decreases in mitochondrial membrane potential and apoptosis in airway epithelial cells via MAPK signaling of human HDM- stimulated bronchial epithelial cells [139]

Mitochondria-Targeted Peptide Cardiolipin-binding tetrapeptide for mitochondrial research SS-31 (Elamipretide) is a synthetic tetrapeptide that selectively concentrates in the inner mitochondrial membrane