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Nitric oxide can be also detrimental to neural tissue if generated in excess by inflammatory cytokines due to the action of inducible nitric oxide synthase (Moncada et al., 1991[41])
pH was kept between 6.0 and 8.5
The trigger is usually reaching a dose that exceeds what their current concentration can deliver in a single syringe draw
Two subsequent studies indicated that this sensitivity of microglia to ferroptosis may be regulated by the expression of intracellular NRF2 or iNOS (Qu et al., 2022)
