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With each cellular division, telomeres shorten slightly and telomere shortening is the main cause of age-related breakdown of cells.65,66 In 2009, the Nobel Prize in Physiology or Medicine was awarded to three scientists for the discovery of how our chromosomes and DNA are protected by telomeres and the enzyme telomerase.67 Telomerase is an enzyme that can place additional DNA repeat sections on the ends of telomeres

Reproductive longevity and aging: geroscience approaches to maintain long-term ovarian fitness

Increasing NAD + levels by supplementing NR in mouse tissues and mammalian cells activates SIRT1 and SIRT3, which ultimately leads to increased oxidative metabolism and prevents metabolic abnormalities induced by HFD

Dis Model Mech (2021) 14(10):dmm049018