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Liver lesions reported in the 2-week study (Medinsky & Irons, 1985) included centrilobular necrosis and severe hydropic degeneration in B6C3F 1 mice at 640 mg/m 3 , hepatocyte necrosis in male CD rats at 180 mg/m 3 and sinusoidal congestion, centrilobular hydropic degeneration and basophilic hepatocyte degeneration in periportal areas at 640 mg/m 3 in rats that died early

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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Guidi C., Potenza L., Sestili P., Martinelli C., Guescini M., Stocchi L., Zeppa S., Polidori E., Annibalini G., Stocchi V