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For heavy drinkers, trying to abstain from drinking for long periods of time, it is significantly challenging, as the brain is programmed to associate drinking with pleasure, and its also triggered by environmental and psychological issues

By inducing ROS accumulation, modulating mitochondrial membrane potential, and activating oxidative stress-related pathways, the nanozyme suppresses tumor proliferation and restores sensitivity to chemotherapeutic agents such as 5-FU [101]

Najjar VA, Holt JRLE (1941) The excretion of specific fluorescent substances in the urine in pellagra

This review will focus on strategies to promote endogenous NO production