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The overall direction of these changes moves gene expression patterns from states associated with disease and aging toward healthier profiles

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Biochem Mol Biol Int 46:519528 Bayrak , Taslimi P, Glin , Menzek A (2017) The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes