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Thus, CBX2 plays a crucial role in remodeling the TIME to support tumor growth and therapy resistance, making it a potential therapeutic target to improve immune responses against tumors ( Figure 3 ) (78)

Astragalus is a dimethylated derivative of resveratrol, which inhibits Top1 enzyme activity and treats colon cancer through the Top1/Tdp1-mediated DNA repair pathway with low toxicity [864]

In vitro investigations revealed that chemo-sonodynamic therapy had greater cytotoxicity than other therapies such as intratracheal cationic liposomal hydroxycamptothecin, intravenous cationic liposomal hydroxycamptothecin, and sonodynamic therapy alone

Flavonoid 4,4-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH