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Mechanistically, the mutated KRAS oncoprotein hypermethylates and silences the expression of multidrug and toxic compound extrusion 1 (MATE1), a specific pump that expels metformin from the tumor cells by upregulating DNA methyltransferase 1 (DNMT1)

Breast Cancer Epigenetics: Normal Human Mammary Epithelial Cells as a Model System

It has been shown that dysregulation of the proBDNF/BDNF axis is intricate in the emergence of several neuropsychiatric conditions, including depression (Pettorruso et al., 2024)

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