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However, a widening of the ring system was productive and the Ang IV analogue 21 with a 13-membered macrocycle exhibited a moderate IRAP inhibitory capacity

Moreover, astaxanthin administration in a type-2 diabetic db/db (leptin receptor mutated) mice improved the intraperitoneal glucose tolerance test and protected pancreatic -cells against glucose toxicity by reducing blood glucose concentration and hyperglycemia-induced oxidative stress [65]
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