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In rats fed a high-fat diet, an increase in visceral fat accumulation and insulinemia were associated with enhanced catalase activity in liver [47], while amelioration of these features by pioglitazone decreased catalase activity [47]

Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum

Borg scale) were monitored every 10 min during exercise

Researchers have identified other mitochondrial-derived peptides, such as Humanin and SHLPs, or small humanin-like peptides, but MOTS-C exhibits unique effects on energy sensing and gene regulation in response to metabolic stress