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Long-term safety requires explicit attention because several carrier classes show persistent brain retention and immune engagement that can evolve into chronic pathology
References 1 Torres-TijiYFieldsFJMayfieldSP
This possibility is underscored by the embryonic or early post-natal lethal phenotypes of mice with inactivating mutations in each of the three mammalian TGF- isoforms, and by the severe auto-immune phenotypes of mice with severely impaired TGF- signaling in T cells or dendritic cells
Liver disease and diabetes: association, pathophysiology, and management
