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The neurotoxicity of rotenone to nigrostriatal dopaminergic neurons was first discovered in an in vivo study in 1985 (Heikkila et al., 1985)

[DOI] [PubMed] [Google Scholar] 109.Yukna RA, Krauser JT, Callan DP, Evans GH, Cruz R, Martin M
cumini methanolic pulp extract could ameliorate the oxidative stress in H9c2 cells caused by malathion, which indicates that it has antioxidant properties and protective effects on malathion-induced cardiotoxicity

This varies by peptide and goal
