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doi: 10.1192/bjp.146.6.576

Not every patient achieves the weight loss targets they are hoping for, and a meaningful proportion of patients even on maximum doses do not reach the 1520% body weight reduction that clinical guidelines increasingly use as a benchmark for meaningful metabolic benefit

J Clin Neurosci 2010;17:1553-6

Its primary effect is appetite suppression, which happens through the activation of satiety centers in the area postrema and nucleus of the solitary tract
