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showed that the production rate of TMAO is not higher in end-stage renal disease (ESRD) patients compared to control subjects [26]

Aging also contributes to synaptic dysfunction, impaired protein homeostasis, calcium dysregulation, and increased permeability of the blood-brain barrier [47]

Although 25 selenoproteins are tissue-specific finetuned in Se deficiency (85) and deiodinase is a highly conserved selenoprotein, the content activity of deiodinase also decreases in severe Se deficiency, when the body synthesizes significantly less T3 and the inhibitory effect on TSH is diminished