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Therefore, the possibility that depression disorders could be effectively influenced by a primary antiulcer agent with cyto-/organo-protective activity such as NaBPC157 was investigated in two rat depression assays: the forced swimming test (a Porsolt's procedure) and the chronic unpredictable stress method (after five days of unpredictable stress protocol, once-daily drug application during the stress procedure and an open field-immobility test assessment at fourth and sixth days of medication)

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The concentration of GSSG was determined by subtracting GSH from tGSH